DCLK1-IN-5 [CAS 3028774-14-0]

DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC50: 179.7 nM). DCLK1-IN-5 inhibits lipopolysaccharide -induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation. DCLK1-IN-5 protects mice against inflammation-induced lung injury and sepsis[1].

[3028774-14-0]

C26H32ClN7O3S2

590.16

O=S(C1=C(NC2=NC(NC3=C(OC)C=C(NC(N4CCN(C)CC4)=S)C=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O

Ser/Thr Protease

10 mM in DMSO

Room temperature