DDR1-IN-12 [CAS 3038810-93-1]

DDR1-IN-12 (Compound 7t) is a highly selective discoidin domain receptor 1 (DDR1) inhibitor (IC50=0.126 μM) . DDR1-IN-12 blocks receptor tyrosine kinase autophosphorylation and downstream signaling (e.g., inhibition of TGF-β1-induced fibroblast activation), inhibiting tumor cell migration and pulmonary fibrosis progression. DDR1-IN-12 is promising for research of lung cancer (especially lung adenocarcinoma) [1].

[3038810-93-1]

C24H25F4N5O2

491.48

O=C(NCC1=CN(CC(N2CCN(CC2)C)=O)C3=C1C=C(F)C=C3)NC4=CC=C(C(F)(F)F)C=C4

Discoidin Domain Receptor

DDR1

Room temperature