DefNEtTrp

DefNEtTrp is a Fe dual chelator ligand, consisting of the Def and Trp moieties. DefNEtTrp exhibits potent and broad-spectrum antiproliferative and cell death behavior in cancer cell lines. DefNEtTrp induces both apoptosis and ferroptosis and has cytotoxicity with an IC50 value of 0.77 μM[1].

C30H27N9O3S

593.66

OC1=C(C2=NN(C3=CC=C(C(NCCNC(N/N=C/C4=C(N)C=CC=N4)=S)=O)C=C3)C(C5=CC=CC=C5O)=N2)C=CC=C1

Apoptosis; Ferroptosis

Room temperature