Dehydroepiandrosterone sulfate [CAS 651-48-9]
Dehydroepiandrosterone sulfate [CAS 651-48-9]
SKU:QM-0138089-01
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Product Details
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Description
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4].
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CAS Number
[651-48-9]
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Molecular Formula
C19H28O5S
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Molecular Weight
368.49
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Smiles
C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OS(=O)(O)=O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3
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Target
GABA Receptor; iGluR; NF-κB; PPAR; Sigma Receptor
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Isoform
Human Endogenous Metabolite; PPARα; Sigma 1 Receptor
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Purity
99.93
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Dehydroepiandrosterone sulfate [CAS 651-48-9]
Dehydroepiandrosterone sulfate is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.