Dehydroepiandrosterone sulfate-d6 (sodium dihydrate)
Dehydroepiandrosterone sulfate-d6 (sodium dihydrate)
SKU:QM-0058752
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Product Details
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Description
Dehydroepiandrosterone sulfate sodium dihydrate-d6 sodium dihydrate is the deuterium labeled Dehydroepiandrosterone sulfate sodium dihydrate. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium dihydrate is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium dihydrate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium dihydrate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium dihydrate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium dihydrate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4][5].
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Molecular Formula
C19H25D6NaO7S
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Molecular Weight
432.54
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Smiles
C[C@@]12[C@]3([H])[C@](CC([2H])=C1C([2H])([2H])[C@@](C([2H])([2H])C2)([2H])OS(=O)(O[Na])=O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C.O.O
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Target
GABA Receptor; iGluR; Isotope-Labeled Compounds; NF-κB; PPAR; Sigma Receptor
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Isoform
PPARα; Sigma 1 Receptor
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Purity
98
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Dehydroepiandrosterone sulfate-d6 (sodium dihydrate)
Dehydroepiandrosterone sulfate-d6 (sodium dihydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.