Dehydroepiandrosterone sulfate (sodium) [CAS 1099-87-2]
Dehydroepiandrosterone sulfate (sodium) [CAS 1099-87-2]
SKU:QM-0158897-01
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Product Details
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Description
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4].
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CAS Number
[1099-87-2]
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Molecular Formula
C19H27NaO5S
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Molecular Weight
390.47
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Smiles
C[C@]1([C@](CC2)([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC1)C2=O
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Target
GABA Receptor; iGluR; NF-κB; PPAR; Sigma Receptor
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Isoform
Human Endogenous Metabolite; PPARα; Sigma 1 Receptor
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Concentration
10mM
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Purity
99.96
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Dehydroepiandrosterone sulfate (sodium) [CAS 1099-87-2]
Dehydroepiandrosterone sulfate (sodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.