Denopterin [CAS 22006-84-4]

Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer[1].

[22006-84-4]

C21H23N7O6

469.45

O=C1C2=NC(C(C)N(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)=CNC2=NC(N)=N1

Antifolate; Nucleoside Antimetabolite/Analog

Von Hippel-Lindau (VHL)

10 mM in DMSO

Room temperature