Denosumab [CAS 615258-40-7]

Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL) . Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies[1][2][3][4][5][6][7].

[615258-40-7]

C6404H9908N1724O2004S50

[Denosumab]

Apoptosis; Caspase; NF-κB; RANKL/RANK

Caspase 3

99.1

H2O

Store at 4°C for 2 years, do not freeze

Blue Ice