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Desmethyl-QCA276 [CAS 2126819-55-2]
Desmethyl-QCA276 [CAS 2126819-55-2]
SKU:QM-0074317
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Product Details
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Description
Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1]. Desmethyl-QCA276 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[2126819-55-2]
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Molecular Formula
C21H17N5OS
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Molecular Weight
387.46
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Smiles
CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(C#CC4=CNN=C4)S5)=C5N21
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Target
Ligands for Target Protein for PROTAC
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Desmethyl-QCA276 [CAS 2126819-55-2]
Desmethyl-QCA276 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.