Desmethylastemizole [CAS 73736-50-2]
Desmethylastemizole [CAS 73736-50-2]
SKU:QM-0052078
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Product Details
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Description
Desmethylastemizole (O-Demethylastemizole), a metabolite of Astemizole , is a β-hematin (βH) inhibitor. Desmethylastemizole has an antiplasmodium activity against P. falciparum with IC50 of 0.12, 0.11 and 0.06 μM for Pf3D7, PfDd2, and PfItG strains, respectively. Desmethylastemizole is also a Histamine H1 receptor antagonist. Desmethylastemizole significantly blocks hERG K+ channels and also inhibits histone-lysine N-methyltransferase EZH2 activity. Desmethylastemizole can be used for long QT syndrome and malaria research[1][2][3].
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CAS Number
[73736-50-2]
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Molecular Formula
C27H29FN4O
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Molecular Weight
444.54
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Smiles
FC(C=C1)=CC=C1CN2C3=CC=CC=C3N=C2NC4CCN(CCC5=CC=C(O)C=C5)CC4
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Target
Drug Metabolite; Histamine Receptor; Parasite; Potassium Channel
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Isoform
H1 Receptor; Plasmodium
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Purity
98.26
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Desmethylastemizole [CAS 73736-50-2]
Desmethylastemizole is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.