Desmethylglycitein [CAS 17817-31-1]
Desmethylglycitein [CAS 17817-31-1]
SKU:QM-0165765-01
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Product Details
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Description
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC) α, against solar UV (sUV) -induced matrix matrix metalloproteinase 1 (MMP1) [2]. Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes[3].
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CAS Number
[17817-31-1]
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Molecular Formula
C15H10O5
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Molecular Weight
270.24
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Smiles
O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(O)C=C13
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Target
CDK; PI3K; PKC
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Isoform
CDK1; CDK2
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Concentration
10mM
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Purity
99.99
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H312, H332
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Precautions
H302, H312, H332
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Desmethylglycitein [CAS 17817-31-1]
Desmethylglycitein is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.