Desvenlafaxine-d6 [CAS 1062605-69-9]

Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine , is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

[1062605-69-9]

C16H19D6NO2

269.41

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC(C1=CC=C(C=C1)O)C2(CCCCC2)O

Isotope-Labeled Compounds; Serotonin Transporter

10 mM in DMSO

Room temperature

H225-H301+H311+H331-H370

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501