DGKα-IN-2 [CAS 2648556-92-5]

DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

[2648556-92-5]

C23H22F3N3O4

461.43

O=C(C1=C(N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(F)F)C4=C(C=CC=C4)N(C)C1=O)N

DGK

98.83

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature