DH-18

DH-18 is a matrix metalloproteinase-2 (MMP-2) inhibitor with the IC50 values of 139.45 nM, 518.11 nM and 833.34 nM for MMP-2, MMP-9 and MMP-8, respectively. DH-18 induces cell apoptosis and arrests cell cycle in the G0/G1 phase. DH-18 inhibits cell growth and can be used for study of chronic myeloid leukemia[1].

C26H23F6N3O5S

603.53

O=C(NCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)CCC(C(NO)=O)NS(=O)(C2=CC=C(C=C2)C3=CC=CC=C3)=O

Apoptosis; MMP

MMP-2; MMP-8; MMP-9

Room temperature