DHP-B

DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis[1].

C23H24O8

428.43

COC1=C2C(OCO2)=CC([C@@H](C3=CC(OC)=C(OC)C(OC)=C3)[C@@]4([H])COC(C4=C)=O)=C1

Apoptosis

10 mM in DMSO

Room temperature