DHU-Se1

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α) . DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1[1].

C23H23N3OSSe

468.47

CN(C1=CC=C2C(SC3=C(N2C([Se]C4=CC=CC=C4)=O)C=CC(N(C)C)=C3)=C1)C

NO Synthase; TNF Receptor

INOS

10 mM in DMSO

Room temperature