DiABZI-i

DiABZI-i is a orthosteric STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNβ in PBMCs with an IC50 of 49 nM. diABZI-i also activates V155M SAVI constitutive signaling in STING V155M THP-1 cells model with potent agonism (EC50: 17 nM) . diABZI-i can be used for monogenic autoinflammatory disease like SAVI disease research[1].

C45H50N12O6

854.96

CCN1N=CC=C1C(/N=C2N(C3=C(N\2C/C(C)=C(CN4C5=C(C=C(C=C5N(/C4=N\C(C6=CC(C)=NN6CC)=O)C)C(N)=O)OCC7=CC=CC(OC)=C7)\C)C=CC(C(N)=O)=C3)C)=O

STING

Room temperature