Didesmethyl cariprazine [CAS 839712-25-3]
Didesmethyl cariprazine [CAS 839712-25-3]
SKU:QM-0079555-01
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Product Details
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Description
Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine. Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (Ki: 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B) ). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons[1][2].
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CAS Number
[839712-25-3]
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Molecular Formula
C19H28Cl2N4O
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Molecular Weight
399.36
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Smiles
O=C(N)N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1
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Target
5-HT Receptor; Dopamine Receptor
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Isoform
5-HT1 Receptor;5-HT2 Receptor; D2 Receptor; D3 Receptor
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Concentration
10mM
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Purity
99.63
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Solubility
DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 80°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Didesmethyl cariprazine [CAS 839712-25-3]
Didesmethyl cariprazine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.