Didesmethylrocaglamide [CAS 177262-30-5]
Didesmethylrocaglamide [CAS 177262-30-5]
SKU:QM-0155293-01
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Product Details
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Description
Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1][2].
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CAS Number
[177262-30-5]
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Molecular Formula
C27H27NO7
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Molecular Weight
477.51
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Smiles
O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(OC)=CC(OC)=C35)N
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Target
Apoptosis; Eukaryotic Initiation Factor (eIF)
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Isoform
EIF4
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Purity
98.84
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Didesmethylrocaglamide [CAS 177262-30-5]
Didesmethylrocaglamide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.