Dihydroberberine [CAS 483-15-8]
Dihydroberberine [CAS 483-15-8]
SKU:QM-0164519-01
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Product Details
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Description
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS -induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy[1][2].
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CAS Number
[483-15-8]
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Molecular Formula
C20H19NO4
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Molecular Weight
337.37
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Smiles
COC1=CC=C(C=C23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
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Target
HSP; Potassium Channel
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Isoform
HSP90
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Purity
99.3
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Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 70°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Dihydroberberine [CAS 483-15-8]
Dihydroberberine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.