Dihydroeponemycin [CAS 126463-64-7]

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis[1].

[126463-64-7]

C20H36N2O6

400.51

CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)C)C([C@]1(CO1)CO)=O)=O)=O

Apoptosis; Proteasome

10 mM in DMSO

Room temperature

H302

P264-P270-P330-P501