β, β-Dimethylacrylshikonin [CAS 24502-79-2]

β, β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β, β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β, β-Dimethylacrylshikonin inhibits Notch-1 activation. β, β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth[1][2][3][4].

[24502-79-2]

C21H22O6

370.4

O=C1C2=C(O)C=CC(O)=C2C(C=C1[C@@H](C/C=C(C)/C)OC(/C=C(C)/C)=O)=O

Apoptosis; Bcl-2 Family; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Notch

99.3

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302, H319, H332, H372, H400

H302, H319, H332, H372, H400