Disitertide (diammonium)

Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a PI3K inhibitor and an apoptosis inducer[1][2][3][4][5].

C68H115N19O22S2

1614.88

O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([O-])=O)CC(N)=O)=O)CCC(N)=O)=O)CCSC)=O)CCSC)=O)C)=O)CC1=CNC2=CC=CC=C12)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CO)=O)C)=O)CC([O-])=O)=O)CC(C)C)=O)CO.[NH4+].[NH4+]

Apoptosis; PI3K; TGF-beta/Smad

99.53

DMSO : 10 mg/mL (ultrasonic) |H2O : 9.09 mg/mL (ultrasonic; adjust pH to 9 with NH3·H2O)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Blue Ice