DM4-SPDP

DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate[1]. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

C45H61ClN4O14S2

981.57

C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@@]([C@@H]([C@](OC5=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N5)O)C)([H])O1

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Maytansinoids

10 mM in DMSO

Room temperature