DMOG [CAS 89464-63-1]

DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[2][4]. DMOG induces cell autophagy[5].

[89464-63-1]

C6H9NO5

175.14

O=C(OC)CNC(C(OC)=O)=O

Autophagy; HIF/HIF Prolyl-Hydroxylase

99.77

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302

H302