DNA Gyrase-IN-9

DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1].

C26H18ClN3O2

439.89

N#CC(C1C2=CC=C(C3=CC=CC=C3)C=C2)=C(O)OC4=C1C(C)=NN4C5=CC=C(Cl)C=C5

Bacterial; DNA/RNA Synthesis

10 mM in DMSO

Room temperature