DNA-PK-IN-12 [CAS 2792146-91-7]

DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC50 of 33.28 μM, and shows antitumor activity in vivo[1].

[2792146-91-7]

C21H24N8O2

420.47

O=C1N(C)C2=CN=C(NC3=C(C)C=C(C4=CN(C)N=C4)N=C3)N=C2N1C5CCOCC5

DNA-PK

99.63

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature