DNA-PK-IN-6 [CAS 2711810-41-0]

DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) [1].

[2711810-41-0]

C19H21N7O

363.42

O=C1N(C)C2=C(N3)N1CCCCCC4=CN=C(C=C5C)N4C=C5/N=C3/N=C2

DNA-PK

10 mM in DMSO

Room temperature