DNH28

DNH28 is a potent NF-κB and MAPK inhibitor with an IC50 of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and Cleaved-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC) [1].

C23H24ClF3N2O

436.9

CCN1CCN(C2=CC(CC/C(C3=O)=C\C4=CC=C(F)C(F)=C4F)=C3C=C2)CC1.Cl

Apoptosis; Bcl-2 Family; Caspase; NF-κB; p38 MAPK

Bax; Bcl-2; Caspase 3; NF-κB

Room temperature