Docetaxel-d5 (trihydrate)

Docetaxel-d5 (trihydrate) is the deuterium labeled Docetaxel (Trihydrate) . Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

C43H54D5NO17

866.96

O=C(OC(C)(C)C)N[C@H]([C@H](C(O[C@@H]1C(C)=C([C@@H](O)C([C@@]2(C)[C@]([C@@](CO3)(OC(C)=O)[C@@]3([H])C[C@@H]2O)([H])[C@@H]4OC(C5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])=O)=O)C(C)(C)[C@@]4(O)C1)=O)O)C6=CC=CC=C6.O.O.O

Apoptosis; Isotope-Labeled Compounds; Microtubule/Tubulin

10 mM in DMSO

Room temperature