DOTAP (methylsulfate) [CAS 144189-73-1]
DOTAP (methylsulfate) [CAS 144189-73-1]
SKU:QM-0202126-01
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Product Details
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Description
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].
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CAS Number
[144189-73-1]
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Molecular Formula
C43H83NO8S
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Molecular Weight
774.19
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Smiles
S(OC)(=O)(=O)[O-].C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C
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Target
Liposome
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Purity
99.94
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Solubility
DMSO : 5 mg/mL (ultrasonic) |Ethanol : 100 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H331, H336, H351, H361, H372
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Precautions
H302, H315, H319, H331, H336, H351, H361, H372
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DOTAP (methylsulfate) [CAS 144189-73-1]
DOTAP (methylsulfate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.