Doxorubicin [CAS 23214-92-8]
Doxorubicin [CAS 23214-92-8]
SKU:QM-0000534
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Product Details
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Description
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy[1][2]. Doxorubicin inhibits human DNA topoisomerase I with an IC50 of 0.8 μM[3].
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CAS Number
[23214-92-8]
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Molecular Formula
C27H29NO11
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Molecular Weight
543.52
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Smiles
COC1=C2C(C(C(C(O)=C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@@]4([H])C[C@H](N)[C@H](O)[C@H](C)O4)C3=C5O)=C5C2=O)=O)=CC=C1
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Target
ADC Payload; AMPK; Antibiotic; Apoptosis; Autophagy; Bacterial; Fluorescent Dye; HBV; HIV; Mitophagy; Topoisomerase
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Isoform
Daunorubicins/Doxorubicins; HIV-1; Topo I; Topo II
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Purity
98.6
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Solubility
10 mM in DMSO
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Doxorubicin [CAS 23214-92-8]
Doxorubicin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.