DPO-1 [CAS 43077-30-1]

DPO-1 is a potent Kv1.5 and Kv1.3 (EC50 = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca2+ influx in Ca2+-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (MSU) -induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K+ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation[1][2][3].

[43077-30-1]

C22H29OP

340.44

CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C

Calcium Channel; Interleukin Related; NOD-like Receptor (NLR) ; Potassium Channel

98.39

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years (Powder)

Blue Ice