DPP8/9-IN-1

DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases[1].

C20H33N2O3PS

412.53

N[C@@H]1C(N(P(OCC)(CCSC(C=C2)=CC=C2CCCCC)=O)CCC1)=O

Dipeptidyl Peptidase

DPP-8; DPP-9

Room temperature