The DR6/TNFRSF21 protein participates in multiple cellular processes and promotes apoptosis through NF-kappa-B activation, BAX-mediated pathways, and cytochrome c release. It is critical for neuronal apoptosis, particularly in response to APP-derived amyloid peptides, and is critical for normal cell body death and axonal pruning. DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.
