DW18134 [CAS 2626988-87-0]

DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides -induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function.

[2626988-87-0]

C24H21N5O3

427.46

CC(O1)(C)CC2=C1C=C(C3=CC=NC=C3)C(NC(C4=COC(C5=CC(N)=NC=C5)=N4)=O)=C2

IRAK

IRAK4

10 mM in DMSO

Room temperature