DYRKs-IN-2 [CAS 1386980-04-6]

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity[1].

[1386980-04-6]

C32H38ClN9O3

632.16

O=C(C1=CC2=CN=C(NCCCN3CCN(C)CC3)N=C2NC1=O)NC4=CC(C(NC(C5=CC=CC=C5)CCN)=O)=CC=C4Cl

DYRK

DYRK1

10 mM in DMSO

Room temperature