E-2508 (free base) [CAS 685885-75-0]

E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (Ki=11 nM) . E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression[1].

[685885-75-0]

C29H39N3O4

493.64

CCC1=NN2C(C3=C(C=C(C=C3OC)COC)OC)=CC=CC2=C1N(CC4CCOCC4)CC5CC5

CRFR

Room temperature