(E) -4- (Naphthalen-2-yl) but-3-en-2-one (Compound 7) is a small active molecule that can be used as building block. (E) -4- (Naphthalen-2-yl) but-3-en-2-one exhibits anti-leukemic activity, that inhibits the proliferation of human chronic myeloid leukemia cell K562 with an IC50 of 7.6 μM[1].