(E) -Belizatinib [CAS 1388225-72-6]

(E) -Belizatinib ((E) -TSR-011) ) (compound 36), the (E) -isomer of Belizatinib , is a potent, selective and orally active anaplastic lymphoma kinase (ALK) Inhibitor with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. (E) -Belizatinib shows >61-fold selectivity over JAK2, SRC, and IGF1R. (E) -Belizatinib shows favorable potency and PK characteristics in rats and dogs. (E) -Belizatinib can be used for ALK-driven cancer research[1].

[1388225-72-6]

C33H44FN5O3

577.73

O=C(C1=CC=C(C=C1)F)NC(N([C@H]2CC[C@H](CC2)C(NC(C)C)=O)C3=C4)=NC3=CC=C4CN5CCC(CC5)C(C)(O)C

Anaplastic lymphoma kinase (ALK)

Room temperature