(-) - (E) -Guggulsterone [CAS 39025-24-6]

(-) - (E) -Guggulsterone ((E) -Guggulsterone) is an orally active natural stereoisomer of Guggulsterone. (-) - (E) -Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-) - (E) -Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-) - (E) -Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-) - (E) -Guggulsterone has cardiac protective and antioxidant activities in rats[1][2][3][4][5][6].

[39025-24-6]

C21H28O2

312.45

C/C=C1C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]/12C)=O)=O

Bacterial; Cytochrome P450; Dengue Virus; Drug Metabolite; Estrogen Receptor/ERR; FXR; Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS)

CYP2C19; CYP2C9; ERα; HO-1

99.19

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H335

H335