(E/Z) -Teriflunomide ((E/Z) -A77 1726) is the active metabolite of Leflunomide. Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA).
CAS Number
[108605-62-5]
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Smiles
C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Target
Dihydroorotate Dehydrogenase
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)