Ebselen oxide [CAS 104473-83-8]

Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM) [1][2][3].

[104473-83-8]

C13H9NO2Se

290.18

O=[Se]1N(C(C2=C1C=CC=C2)=O)C3=CC=CC=C3

Guanylate Cyclase

98

DMSO : 5 mg/mL (ultrasonic; warming)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice

H301+H331-H315-H335-H373-H410

P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P403+P233-P405-P501