ECF506-d5

ECF506-d5 (NXP900-d5) is deuterated labeled eCF506. eCF506 is a highly potent and orally active YES1/SRC kinase inhibitor with an IC50 of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer[1][2][3].

C26H33D5N8O3

515.66

[2H]C1(CN(CC([2H])(C1(N(C)C)[2H])[2H])CCN2N=C(C(C2=NC=N3)=C3N)C4=CC=C(C(OC)=C4)NC(OC(C)(C)C)=O)[2H]

Isotope-Labeled Compounds; Src

10 mM in DMSO

Room temperature