Echinomycin [CAS 512-64-1]

Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2].

[512-64-1]

C51H64N12O12S2

1101.26

[H]C1=NC2=C(N=C1C(N[C@H](COC([C@H](C(C)C)N(C)C([C@H]3N4C)=O)=O)C(N[C@@H](C)C(N(C)[C@@H]([C@@H](SC)SC3)C(N(C)[C@@H](C(C)C)C(OC[C@@H](NC(C5=NC6=C(C=CC=C6)N=C5[H])=O)C(N[C@@H](C)C4=O)=O)=O)=O)=O)=O)=O)C=CC=C2

Antibiotic; Bacterial; HIF/HIF Prolyl-Hydroxylase

98.57

DMSO : 5.3 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice

H301, H311, H331, H361

H301, H311, H331, H361