The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, Fc) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag.