Eg5-IN-3

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol.

C23H23N7O2

429.47

CN1C(N=C(NCCCN2C=NC=C2)N3CC4=CC=C(C=CC=C5)C5=C4)=C3C(NC1=O)=O

Kinesin; Microtubule/Tubulin

Room temperature