EIF4A3-IN-11 [CAS 1402931-70-7]

EIF4A3-IN-11 (compound 56) is a Silvestrol analogue. eIF4A3-IN-11 interferes the assembling of eIF4F translation complex with EC50s of 0.2, 4 and 0.3 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-11 can be used for the research of human cancer pathogenesis[1].

[1402931-70-7]

C29H28O9

520.53

COC1=CC=C([C@@]23OC4=CC(C(OC)=O)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1

Eukaryotic Initiation Factor (eIF)

99.24

10 mM in DMSO

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature