EIF4A3-IN-17 [CAS 1402931-75-2]

EIF4A3-IN-17 (compound 61) is a Silvestrol analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis[1].

[1402931-75-2]

C28H25NO7

487.5

COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1

Eukaryotic Initiation Factor (eIF)

99.56

10 mM in DMSO

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature