EIF4E-IN-6

EIF4E-IN-6 (compound 4b) is a GMP analogs synthesized to targeteIF4Eand restrain its binding to cap mRNA.eIF4E-IN-6shows cell cytotoxicity against Caco-2, HepG-2, and MCF-7 cells, withIC50values of 31, 27, and 21 μM, respectively[1].

C33H32BrN9NaO12P

880.53

O=C1NC(NC(C2=CC=CC=C2)=O)=NC3=C1[N+](CC4=CC=CC=C4)=CN3C5OC(COP(NNC6=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C6)(O[Na])=O)C7C5OC(C)(C)O7.[Br-]

Eukaryotic Initiation Factor (eIF)

10 mM in DMSO

Room temperature